Abstract:The Red River fault is one of the major regional active faults in China,it had been divided into the southern and northern segments according to the features of seismogeology,A new segmentation method,geochemical segmentation method,is introduced in this paper. Based on the features of densities. reservoir temperatures,circulating depths and concentrations of CO2,HCO2-,SO4- F,Li,Sr and B of the worm springs along the fault,the northern segment is further divided into four sub-segments,The seismic activities along these sub-segments of the fault differ from each other,which is thought to be mainly caused by the differences in weakness degree of each sub-segment due to the fluids in the fautl zone.