Abstract:In this paper,by themethod of grep catastrophic prediction,the seismic grey prediction models of Yangzhou-Tongling seismotectonic belt Ms≥5.0 and Ms≥4.0 are built respec-tively, according to the time intervals between two moderately strong earthquakes or the origin times of all previous moderately strong earthquakes. It shows that the prediction accuracy and result are pleasing,by the prediction practice in recent years;and the method of grey predic-tion can be one of comprehensive earthquake prediction.